What if aging skin cells could be reset to behave like younger ones?
Dr. Doris Day returns to The Dr. Randi Show to introduce Re-Q, the new serum from Rapalogix designed to reset aging skin cells. She explains why the cells responsible for producing collagen become exhausted over time and how Re-Q is designed to help them repair, recover and function more like younger cells. In laboratory testing, fibroblasts from 56-year-old skin behaved like 23-year-old fibroblasts after treatment.
But this conversation is about much more than one product. Dr. Day shares why she believes aesthetics is entering an entirely new era centered on longevity, where the goal is not simply to erase wrinkles but to help the skin remain healthier, stronger and more resilient as we age.
They discuss:
- How Re-Q resets aging skin cells
- What makes Re-Q different from traditional skincare
- How Re-Q works alongside retinoids, lasers, fillers and biostimulators
- What Rapalogix is developing next for the body, eyes and hair
- Combining fillers, biostimulators and devices to improve skin quality
- Her honest take on regenerative medicine, exosomes, peptides, GLP-1s, hormone optimization and other longevity trends
Dr. Day also officially joins The Dr. Randi Show Expert Council, bringing her expertise in dermatology, longevity and aesthetic medicine to future conversations on the show.
From resetting aging skin cells to regenerative medicine and the future of aesthetics, this episode explores what it could mean to help our skin not only look younger, but age better.
Sponsored by NewBeauty 💄
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Episode FAQ
What does this episode of The Dr. Randi Show cover?
This episode of The Dr. Randi Show features board-certified dermatologist Dr. Doris Day, who returns to the show and joins its Expert Council. The conversation covers her new skin-longevity company Rapalogix Health and its Re-Q Pro-Longevity Face Serum, how the serum is designed to support aging skin cells, how she layers it with existing skincare and in-office treatments, what she is seeing with filler trends and the natural look, how perimenopause and menopause affect the skin, her interest in topical estrogen, and the collagen-building treatments she is most excited about. Everything she shares reflects her own experience and clinical observations, and is not medical advice.
What is the Re-Q Pro-Longevity Face Serum and the skin-longevity idea behind it?
On this episode of The Dr. Randi Show, Dr. Day describes Re-Q as a longevity product you apply to your skin rather than a traditional skincare product. She explains that after close to 30 years in practice she noticed collagen-building treatments worked less well as women aged, which led her to focus on the fibroblast, the skin cell that produces collagen and elastin. In her account, fibroblasts become exhausted and senescent with age and can even affect nearby healthy cells, so Re-Q is built around supporting and resetting those cells. She co-founded Rapalogix Health to develop it, and the serum is formulated with a selective TORC1 inhibitor called RLX-201. This reflects the guest’s perspective and is not medical advice.
How does inhibiting the TORC1 pathway aim to reset aging skin cells?
In this episode, Dr. Day explains that TORC1 is a cellular pathway, part of the mTOR system, that tells cells to keep working. She says that with age this pathway can get stuck in the on position, pushing fibroblasts into overdrive, much like running a marathon every day without rest until the cell tires and gets injured. According to the guest, the RLX-201 molecule in Re-Q is a selective TORC1 inhibitor that does not switch the pathway off but resets it, giving cells room to repair. She reports that in laboratory work, 56-year-old fibroblasts treated this way behaved like 23-year-old fibroblasts, and that placebo-controlled human studies with biopsies followed. These are her descriptions of her company’s research, shared for general interest and not as medical advice.
How is the Re-Q serum used alongside retinoids, vitamin C, lasers, and other treatments?
On the show, Dr. Day recommends applying Re-Q first, as a base layer, before other products. She frames it as something that does not replace retinoic acid, vitamin C, or laser treatments but primes the fibroblast so those treatments can work better, helping the cell make healthier collagen. She says she used it twice a day in her studies and suggests using it for at least two weeks before an in-office procedure to prepare the skin, then resuming several days afterward depending on the treatment. In her real-world office study, she reports patients added Re-Q to an existing routine without pilling or trouble layering makeup on top. This reflects the guest’s personal clinical approach, not medical advice.
How soon might results appear, and who does the guest consider a good candidate?
In this episode, Dr. Day frames Re-Q as a longevity serum, so she encourages thinking about long-term skin health rather than a quick before-and-after. That said, she notes botanical ingredients such as curcumin were built in to give more immediate improvements in tone and quality, and that people tend to notice results within a few weeks and generally within a month. She considers it suitable for essentially anyone over 30 and says she does not recommend it for people under 30. If choosing one time of day, she suggests night, since that is when skin repairs, though she tested it twice daily. These are the guest’s personal recommendations and observations, not medical advice.
Did the guest observe any effect on easy bruising or fragile skin?
On the show, Dr. Day shares anecdotes from her own practice rather than universal results. She describes a patient on a blood thinner with senile purpura, also called dermatoporosis, who reported less bruising on his arms after using Re-Q, and another very sensitive patient who tolerated the product and bruised less after injections. She connects this to the idea that supporting the skin’s extracellular matrix may make it more resilient, while noting this is an area she wants to study further. These are individual experiences the guest reported, not proven or universal outcomes, and nothing here is medical advice.
What filler trends is the guest seeing, and is the natural look back?
In this episode, Dr. Day says her practice has long favored natural-looking results, with patients asking to dissolve older filler and start over in areas like the under-eyes, lips, and around the mouth. She describes the current direction as combining approaches, using biostimulators together with fillers and devices so that each plays a specific role, rather than relying on one product to solve everything. She also emphasizes celebrating a person’s natural features and bone structure rather than trying to change them. This reflects the guest’s personal philosophy and practice, not medical advice.
How do perimenopause and menopause affect the skin?
On the show, Dr. Day explains that many changes women notice in perimenopause, such as skin suddenly feeling like it fell apart, new breakouts, dryness, or changes in hair, tie back to declining estrogen and a shifting skin microbiome. She notes the face, neck, and scalp carry a high concentration of estrogen beta receptors, and that when estrogen falls the skin tends to be sacrificed before other organs. She adds that without hormone therapy a person can lose a meaningful share of collagen in the first years after menopause. In her view, menopause hormone therapy tends to benefit bones, heart, and brain more than skin. This is the guest’s clinical perspective, shared for general information and not as medical advice.
What does the guest think about topical estrogen for the skin?
In this episode, Dr. Day shares that she is running a clinical trial on topical estrogen for the skin, using epigenetic testing on skin swabs, because she wants hard data on what it does. She explains that skin carries estrogen beta receptors while reproductive organs carry alpha receptors, and in her view applying estrogen to the face acts on those beta receptors at a low concentration over a small surface area, so she does not believe it causes harm, though she is careful not to claim it prevents cancer. She also notes that women on menopause hormone therapy may still benefit from vaginal estrogen for the mucosa. These are the guest’s opinions and ongoing research, not medical advice.
Which treatments does the guest highlight for rebuilding collagen and skin quality with age?
On this episode of The Dr. Randi Show, Dr. Day highlights several treatments she uses to support collagen and skin quality. She speaks highly of Sofwave for building collagen with no downtime, and shares excitement about a laser called UltraClear that offers a coring setting for tightening and is designed to be safe in all skin types. She also uses biostimulators such as Sculptra, a poly-L-lactic acid product she studied in menopausal women for Galderma, and hyperdilute Radiesse, a calcium hydroxyapatite product, often combined with fillers so results look natural. She frames early sun protection and good nutrition as the foundation. These reflect the guest’s personal clinical preferences and are not medical advice.
