This week on The Dr. Randi Show, we’re going straight to the source of one of the most talked-about breakthroughs in aesthetics: platelet-derived exosomes.
I sit down with Alisa Lask, CEO of Rion Aesthetics and the visionary force behind ( plated )™ Skin Science , the award-winning skincare brand born out of Mayo Clinic regenerative medicine research and backed by more than $150 million in science.
This isn’t hype skincare. This is biotech. Alisa breaks down how a regenerative discovery turned into a professional-grade skincare line now used in thousands of clinics nationwide, why platelet-derived exosomes are different from plant and stem-cell claims, and how Plated became the only skincare line recognized as TIME’s Best Innovation of the Year, while also earning top industry honors from NewBeauty and beyond.
In this episode, we cover:
🔹Why platelet-derived exosomes are becoming the gold standard
🔹The truth about plant exosomes vs human communication
🔹 How Mayo Clinic science made its way into aesthetics
🔹 The awards, data, and credibility behind Plated’s rapid rise
🔹 What’s coming next in regenerative medicine, and why it matters now
If you care about results, science, and where aesthetics is headed next, this is a must-listen.
Sponsored by NewBeauty💄
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🎧 Listen Now on Apple: https://dub.link/df1cXzd
Episode FAQ
What is Plated skincare and the regenerative aesthetics approach behind it?
On this episode of The Dr. Randi Show, Alisa Lask, CEO of Rion Aesthetics and the leader behind the Plated skincare line, shares her perspective on regenerative aesthetics. She describes it as skincare that uses the power of the human body to renew skin, rather than relying on chemicals or plant ingredients. The centerpiece of the conversation is platelet-derived exosomes, a technology that originated in cardiac regenerative medicine research at the Mayo Clinic. In the guest’s view, the goal is to bring proof rather than promise to skincare, backed by science and clinical study.
What are platelet-derived exosomes and how do they work in skincare?
On The Dr. Randi Show, the guest explained that exosomes are the body’s cell-to-cell communication system, and that we naturally carry thousands of them. She noted that not all exosomes send the same signal, and that the ones used in Plated are sourced from platelets because they signal skin and cell renewal. She compared platelets to the body’s first responders to a wound, which is why she believes they have a unique ability to renew skin. This reflects the guest’s explanation of her own product’s technology.
How did exosome technology go from Mayo Clinic research to a skincare brand?
According to the guest on The Dr. Randi Show, the science behind Plated came out of the Van Cleve Cardiac Regenerative Medicine Center at the Mayo Clinic, where interventional cardiologists had studied regenerative medicine for more than 20 years. She recounted that researchers who wore gloves in the lab noticed their dry, irritated hands looked remarkably better after applying the platelet-derived technology, which prompted the founder and his wife to explore a beauty application. The guest joined to consult on the medical side and concluded the technology was special enough to build a professional-grade brand around.
What makes platelet-derived exosomes different from plant or stem cell exosomes?
On The Dr. Randi Show, the guest said Plated uses platelet-derived exosomes because platelets are acellular, meaning they have no cell nucleus, so there is less concern about DNA compared with other human-derived sources such as adipose tissue or MSCs. She contrasted this with plant-derived exosomes, which in her view cannot communicate with human cells and offer nutrients more like eating a carrot. Her point was that the source of an exosome matters a great deal, and that platelet-derived human exosomes are different from plant or stem cell versions.
Why do exosomes need to be shelf stable, and what makes Plated’s technology proprietary?
On The Dr. Randi Show, the guest explained that Plated’s exosome technology, which she referred to as Renewsome, is proprietary and patented, and that no other brand can offer platelet-derived exosomes. She described exosomes as fragile, comparing an intact exosome to a farm-fresh egg protected by a lipid barrier that is almost instantly destroyed if cracked or placed in a formulation with the wrong ingredients or pH. In her account, the real science is keeping the right exosomes shelf stable and still active inside the bottle, which she said took roughly 15 years and 150 million dollars in research.
What products are in the Plated line and what does each one do?
On The Dr. Randi Show, the guest walked through the Plated line and how the names match what each product does. Intense was the first product created and has the highest concentration of exosomes, which she described as the brand’s bestseller for people wanting the most impact. Calm is designed to support recovery after treatment and, she noted, can also prime the skin beforehand, with published clinical results she says show it can help reduce downtime. Daily is an everyday option she described as more cost effective, and there is also an eye serum popular with a younger audience. She added that the packaging is refillable, which she said makes Plated the first refillable in the professional channel.
How should you apply Plated exosome products for the best results?
On The Dr. Randi Show, the guest stressed that Plated products work best on clean skin, because platelet-derived exosomes do not like many common ingredients found in sunscreens, cosmetics, toners, or makeup wipes. She shared that oils in particular can destroy exosomes, so if you remove makeup with an oil-based product you should rinse your face first. Her guidance was to apply the exosomes to clean skin, which can be damp, wait a few minutes for them to absorb, and then continue with the rest of your routine. She also noted the technology is flexible on timing, and suggested using it opposite a retinoid so the two are not applied together.
Does Plated make a hair product, and what does the research show?
On The Dr. Randi Show, the guest described how Plated expanded from skin to hair after customers began asking about it. She explained that the brand ran a double-blind, randomized, placebo-controlled study with an internationally recognized plastic surgeon and published statistically significant results in a peer-reviewed journal. She said the product is easy to use, applied in the morning with a single dropper, and is not greasy and does not affect hair color. She cautioned that hair takes about four to six months to show a difference, so consistency and patience matter, and noted she often sees postpartum and postmenopausal women dealing with hair loss.
What are the biggest misconceptions about exosomes in skincare?
On The Dr. Randi Show, the guest named a few misconceptions she hears most often. First, that plant exosomes work like human ones, which she disputes, saying there is no published data showing plant exosomes can communicate with human cells. Second, that all exosomes are the same, when in her view sourcing the right ones requires a high level of sophistication. Third, that exosomes can do almost anything, which she connected to over-promises and FDA warning letters around extreme claims. Her advice was to look for real science and proof and to work with a provider rather than buying unverified skincare online.
What is coming next for Plated and regenerative aesthetics in 2026?
Looking ahead on The Dr. Randi Show, the guest said Plated plans to keep innovating in 2026. She mentioned an ongoing hair study that also looks at eyebrows, and interest in developing products for the body. She also described longer-term work on FDA trials for injectable exosome treatments for hair loss and wrinkles, using what she called a purified exosome product, or PEP, which she distinguished from the topical cosmetic line. She emphasized that no exosomes are currently FDA approved for injection and that Plated’s current products are for topical use only, and said the company only puts its name on products once the science supports them.
